paradigm shift

REPURPOSING


Established drugs can be repurposed for new clinical indications for unmet medical needs when protected by strong intellectual property. Historical drug safety data and existing manufacturing ‘know-how’ can fast-track clinical development and reduce commercialisation costs for repurposed drugs.

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UNDERSTANDING COMPLEXITY


Life is complex! For every diagnosis, there are multiple factors and biological interactions involved. We develop therapeutics targeting multiple pathways involved in injury or on the road to disease producing better outcomes for patients.

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our focus

PENTOSAN POLYSULPHATE SODIUM (PPS)


We focus on PPS because this FDA approved drug has a long history of safety and efficacy in treating interstitial cystitis and deep vein thrombosis. Our patents cover new applications in bone marrow edema (BME) and respiratory disease.

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INFLAMMATION


Inflammation is a complex biological response to injury, infection or allergy, which has short and long term components mediated by factors produced by immune cells.

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announcements

Paradigm Phase 2 Ross River Virus Clinical Trial Update

14 September 2017

Paradigm Biopharmaceuticals Ltd. is pleased to announce strong momentum with its Phase 2 Ross River virus clinical trial…

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A paradigm shift in treating osteoarthritis pain

11 September 2017

Paradigm Biopharmaceuticals Ltd. (ASX:PAR) is pleased to announce the peer-reviewed publication of a patient case study…

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Paradigm – First Ross River Trial Participant Treated

9 August 2017

Paradigm Biopharmaceuticals announces that it has successfully dosed its first patient in its Phase 2 Alphavirus clinical trial…

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key statistics

Alpharirus

Alphaviruses, including Ross River virus (RRv) and Chikungunya (CHIKV) are mosquito-transmitted arthritogenic alphaviruses that cause epidemics of severe musculoskeletal disease.

*Simon, Fabrice et al. “Chikungunya Virus Infection.” Current Infectious Disease Reports 13.3 (2011): 218–228. PMC. Web. 10 Oct. 2016


Osteoarthritis (OA)

OA is a condition with a significant unmet medical need. Opioid abuse resulting from mismanagement of pain is a major problem in the US and most western countries.

*National Institute of Health; Emerging drugs for osteoarthritis; Hunter DJ and Matthews G 16(3): 479–491; 2011 September


Bone Marrow Edema (BME)

Worldwide hip & knee surgical implant market is $16.7 billion, will be $33 billion by 2022. Acute joint injury leads to osteoarthritis.


Bone Marrow Edema (BME)

>50% top ranked skiers have injured knee ligaments (women 5x more susceptible than men)

clinical

PIPELINE


RESEARCH & DEVELOPMENT

Paradigm is evaluating new intellectual property that has relevance to treating inflammation, especially in orthopaedics.


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our partners

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